Can We Better Optimize Vancomycin Monotherapy?

Antenatal steroids: can we optimize the dose?

PURPOSE OF REVIEW The beneficial effects of antenatal steroids in women at risk of preterm birth are evident. A dose of 24 mg appears sufficient, but there are insufficient data to recommend betamethasone or dexamethasone, a single steroid dose, the optimal interval between doses and repeated courses, the gestational age at which treatment is beneficial and the long-term effects of steroid trea...

Can We Optimize Toeplitz/Hankel Computations?

The classical and intensively studied problem of solving a Toeplitz/Hankel linear system of equations is omnipresent in computations in sciences, engineering and communication. Its equivalent formulations include computing polynomial gcd and lcm, Padé approximation, and BerlekampMassey’s problem of recovering the linear recurrence coefficients. To improve the current record asymptotic bit opera...

We must--and we can--do better.

When can we do better than autarky?

This paper provides a necessary and sufficient condition for the existence of nonautarkic contract in a risk sharing model with two-sided lack of commitment. Verifying the condition takes just one Gaussian elimination of a matrix. Published by Elsevier B.V.

Juvenile thyrotoxicosis; can we do better?

Thyrotoxicosis remains a frustrating condition for the young person, family, and health professionals involved. The associated symptoms do not always suggest thyroid disease and patients can be unwell for many months before the diagnosis is made. The antithyroid drug regimen used to treat children and adolescents with thyrotoxicosis varies from one unit to another and yet the potentially life t...